Neuregulin 1 improves complex 2-mediated mitochondrial respiration in skeletal muscle of healthy and diabetic mice
Abstract It has been reported that neuregulin1 Football (NRG1) improves glucose tolerance in healthy and diabetic rodents.In vitro studies also suggest that NRG1 regulates myocyte oxidative capacity.To confirm this observation in vivo, we evaluated the effect on mitochondrial function of an 8-week treatment with NRG1 in db/db diabetic mice and C57B